Abbrev. T, Thr
Full Name Threonine
Side chain type hydrophilic
Side chain -CH(OH)CH3
Hydro- phobic yes
Aromatic or Aliphatic no
van der Waals volume 93
Codon ACU, ACC, ACA, ACG
Occurrence in proteins (%) 5.9
Remarks: Essential for humans. Behaves similarly to serine.
Threonine is one of the 20 natural amino acids. Nutritionally, in humans, threonine is an essential amino acid.
Threonine contains two chiral centers, so there are four possible stereoisomers of threonine, or two possible diastereomers of L-threonine. However, the name L-threonine is used for one single enantiomer, (2S,3R)-2-amino-3-hydroxybutanoic acid. The second diastereomer (2S,3S), which is rarely present in nature, is called L-allo-threonine.
The threonine side chain can undergo O-linked glycosylation.
Threonine can become phosphorylated through the action of a threonine kinase. In its phosphorylated form, it can be referred to as phosphothreonine.
Foods high in threonine are cottage cheese, poultry, fish, meat, lentils, and sesame seeds.
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