Steroid hormone

Steroid hormones are steroids which act as hormones. They can be grouped into five groups by the receptors to which they bind: glucocorticoids, mineralocorticoids, androgens, estrogens, and progestagens. Vitamin D derivatives are a sixth closely related hormone system with homologous receptors, though technically sterols rather than steroids.

Overview

The natural steroid hormones are generally synthesized from cholesterol in the gonads and adrenal glands. Steroid hormones are generally carried in the blood bound to specific carrier proteins such as sex hormone binding globulin or corticosteroid binding globulin. Further conversions and catabolism occurs in the liver, other "peripheral" tissues, and in the target tissues.

Because steroids and sterols are lipid soluble, they can diffuse fairly freely from the blood through the cell membrane and into the cytoplasm of target cells. In the cytoplasm the steroid may or may not undergo an enzyme-mediated alteration such as reduction, hydroxylation, or aromatization. In the cytoplasm, the steroid binds to the specific receptor, a large metalloprotein. Upon steroid binding, many kinds of steroid receptor dimerizes, two receptor subunits join together to form one functional DNA-binding unit that can enter the cell nucleus. In some of the hormone systems known, the receptor is associated with a heat shock protein which is released on the binding of the ligand, the hormone. Once in the nucleus, the steroid-receptor ligand complex binds to specific DNA sequences and induces transcription of its target genes.

Synthesis

Steroids made from Cholesterol:

Principal natural human steroid hormones

- Glucocorticoids - cortisol
- Mineralocorticoids - aldosterone
- Sex steroids - Androgens - testosterone
- dehydroepiandrosterone (DHEA)
- dehydroepiandrosterone sulfate (DHEAS)
- androstenedione
- dihydrotestosterone (DHT)
- Estrogens - estradiol
- estrone
- estriol
- Progestagens - progesterone

The principal sterol hormone:

- Vitamin D derivatives - calcitriol

Synthetic steroids and sterols

A variety of synthetic steroids and sterols have also been contrived. Most are steroids but some non-steroidal molecules can interact with the steroid receptors because of a similarity of shape. Some synthetic steroids are weaker, some much stronger, than the natural steroids whose receptors they activate.

Some examples of synthetic steroid hormones:

- Glucocorticoids: prednisone, dexamethasone, triamcinolone
- Mineralocorticoid: fludrocortisone
- Vitamin D: dihydrotachysterol
- Androgens: oxandrolone, decadurabolin (also known as anabolic steroids)
- Estrogens: diethylstilbestrol (DES)
- Progestins: norethindrone, medroxyprogesterone acetate

Steroidogenic enzymes: Review on structure, function, and role in regulation of steroid hormone biosynthesis

___________________

Go to Start | This article uses material from the Wikipedia